Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects
نویسندگان
چکیده
منابع مشابه
interpersonal function of language in subtitling
translation as a comunicative process is always said to be associated with various aspects of meaning loss or gain. subtitling as a mode of translating, due to special discoursal and textual conditions imposed upon it, is believed to be an obvious case of this loss or gain. presenting the spoken sound track of a film in writing and synchronizing the perception of this text by the viewers with...
15 صفحه اولFrontotemporal lobar degeneration through loss of progranulin function.
The striking clinical and pathological features of frontotemporal lobar degeneration (FTLD) have attracted much attention ever since Arnold Pick reported the first disease cases and Alois Alzheimer described the characteristic nerve cell inclusions of Pick’s disease. We now know that FTLD is a common cause of dementia, especially in the population below the age of 65 (Neary et al., 2005). Clini...
متن کاملMolecular Mechanisms of Frontotemporal Lobar Degeneration
List of Papers This thesis is based on the following papers, which are referred to in the text by their Roman numerals. A. Frontotemporal dementia in a large Swedish family is caused by a progranulin null mutation. No evidence of PGRN or MAPT gene dosage alterations in a collection of patients with frontotempo-ral lobar degeneration. Manuscript Reprints were made with permission from the respec...
متن کاملGenetics of Frontotemporal Lobar Degeneration
Frontotemporal lobar degeneration (FTLD), the most frequent neurodegenerative disorder with a presenile onset, presents with a spectrum of clinical manifestations, ranging from behavioral and executive impairment to language disorders and motor dysfunction. Familial aggregation is frequently reported, and about 10% of cases have an autosomal dominant transmission. Microtubule associated protein...
متن کامل[Frontotemporal lobar degeneration].
Article abstract-Objectiue: To improve clinical recognition and provide research diagnostic criteria for three clinical syndromes associated with frontotemporal lobar degeneration. Methods: Consensus criteria for the three prototypic syndromes-frontotemporal dementia, progressive nonfluent aphasia, and semantic dementia-were developed by members of an international workshop on frontotemporal lo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Neuropathologica
سال: 2012
ISSN: 0001-6322,1432-0533
DOI: 10.1007/s00401-012-1030-4